Stoichiometric Ecotoxicology for a Multisubstance World

Ecotoxicology.

Fish models for ecotoxicology

1. Laboratory models Fish laboratory models covering different parts of the life cycle and different routes of exposure are continuously developed and modified in order to meet new challenges. The most important exposure routes are by injection, trough contaminated water or feed [1]. For laboratory studies zebrafish (Danio rerio), medaka (Oryzias latipes), fathead minnow (Pimephales promelas) a...

Comparing chemical fingerprints for ecotoxicology

We present a comparison between 14 chemical fingerprints using 1D/2D features and PMCSFG, a data mining method that induces features based on maximum common subgraphs. We provide an experimental evaluation and discuss the usefulness of the different methods on ecotoxicology data. The features generated by data mining yield a similar performance for predicting toxicity, while they are more inter...

Ethics in science: ecotoxicology

Predictive ecotoxicology emphasizes the probable environmental outcome of exposure to toxics, rather than the mere appraisal of existing damage, and in so doing raises some complex but interesting ethical issues. Awareness of endocrine-disrupting chemicals is blurring the line between humankind and other life forms in toxicity testing by providing evidence that both humans and wildlife suffer a...

Toward a stoichiometric framework for evolutionary biology

Ecological stoichiometry, the study of the balance of energy and materials in living systems, may serve as a useful synthetic framework for evolutionary biology. Here, we review recent work that illustrates the power of a stoichiometric approach to evolution across multiple scales, and then point to important open questions that may chart the way forward in this new field. At the molecular leve...